Abstract #2291

Age Dependency of Diffusion-Relaxation Coupling in the Prostate

Albert Yen^1,2,3, Enamul Bhuiyan¹, Qingfei Luo^1,4, Kaibao Sun¹, Guanyu Dan¹, and Xiaohong Joe Zhou^1,3,4,5

¹Center for Magnetic Resonance Research, University of Illinois Chicago, Chicago, IL, United States, ²Medical Scientist Training Program, University of Illinois Chicago, Chicago, IL, United States, ³Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, United States, ⁴Department of Radiology, University of Illinois Chicago, Chicago, IL, United States, ⁵Department of Neurosurgery, University of Illinois Chicago, Chicago, IL, United States

Synopsis

Keywords: Prostate, Prostate, fast acquisition

Motivation: Luminal water imaging (LWI) strongly correlates with Gleason scores in the prostate, but conventional LWI imaging techniques are time consuming and may be confounded by age.

Goal(s): Investigate the age dependency of luminal water fraction and other LWI parameters in the prostate.

Approach: Use time-efficient multi-readout EPI sequences capable of acquiring images at multiple TEs in one shot to probe T2-ADC and T2*-ADC coupling in the prostate among healthy male subjects.

Results: LWI parameters showed weak to moderate correlations with age.

Impact: This study demonstrates the feasibility of using multi-readout DWI sequences to enable time-efficient investigation of age dependency of LWI parameters, providing valuable information for using LWI to evaluate prostate lesions.

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