Abstract #2295

Multicenter Validation of Amide Proton Transfer Imaging for Molecular and Grade Classification of Adult-Type Diffuse Gliomas

Tongling Jiang¹, Minghao Wu², Junjiao Hu³, Yicheng Hsu⁴, Hu Guo³, Xiaoyue Ma⁵, Yaou Liu², and Yi Zhang¹

¹Zhejiang University, Hangzhou, China, ²Department of Radiology, Beijing Tiantan Hospital, Beijing, China, ³Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China, ⁴MR Collaboration, Siemens Healthcare Ltd, Shanghai, China, ⁵Department of Magnetic Resonance Imaging, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Synopsis

Keywords: CEST / APT / NOE, Brain

Motivation: Precise glioma classification is essential for personalized treatment, but non-invasive tools struggle with molecular differentiation. APT imaging shows promise, yet multicenter validation is lacking.

Goal(s): This prospective study evaluates APT imaging’s ability to classify adult-type diffuse gliomas by grade, subtype, and IDH status across multiple centers.

Approach: Using standardized MRI protocols, 123 patients from three centers were analyzed. APT metrics were assessed for consistency and diagnostic performance.

Results: APT imaging reliably distinguished glioma grades and IDH mutations across centers, though some challenges remain in differentiating certain subtypes.

Impact: This study demonstrates that APT imaging reliably differentiates adult-type gliomas across centers, enabling more precise, non-invasive tumor characterization. It promotes earlier, molecularly informed diagnoses, guiding personalized treatment strategies and fostering research on APT imaging's prognostic and therapeutic potential.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.