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Abstract #2297

Mitigation of T1 impact for unbiased tumor APT MRI using quasi-steady-state based apparent exchange-dependent relaxation analysis

Zhou Liu1, Qian Yang1, Haizhou Liu1, Honghong Luo1, Yijia Zheng1, Wei Cui2, Dehong Luo1, and Yin Wu3
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, 2MR Research China, GE Healthcare, Guangzhou, China, 3Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE

Motivation: T1 confounds CEST measurements, leading to reduced specificity and misinterpretation of CEST MRI.

Goal(s): The study aimed to investigate the feasibility of quasi-steady-state (QUASS)-based apparent exchange-dependent relaxation (AREX) analysis in correcting T1.

Approach: CEST MRI experiments were conducted on a creatine phantom and brain tumor patients. Conventional CEST effect was quantified with the asymmetry analysis for the phantom or a multipool Lorentzian function for human brains from QUASS Z-spectra. The AREX metric with T1 correction was calculated from the inverse of QUASS Z-spectra.

Results: Substantial T1 impact was shown on conventional CEST images, whereas the QUASS-based AREX measurements were less affected by T1.

Impact: The QUASS-based AREX analysis can effectively correct the T1 confoundment in CEST measurements, facilitating unbiased tumor CEST MRI at 3 T.

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Keywords