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Abstract #2304

31P-CEST “matrix” for in vivo rat brain: novel apparent Z spectra analysis towards sensitive imaging

Nan Gao1, Yi Wang1,2,3, Jia-Hong Gao3, and Xiaolei Song1
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2School of Public Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin, China, 3Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE

Motivation: There was a lack of systemic CEST-type experiments and further analysis for 31P-MRS, towards detailed interaction quantification and novel sensitive detection scheme.

Goal(s): Through a comprehensive 31P-CEST "matrix" study, to explore an accelerated 31P-CEST scheme for sensitive imaging.

Approach: 31P-CEST experiments were performed on in vivo rat brain at 9.4T, with novel apparent Z spectra calculated using PCr, Pi, PME, and α/β/γ-ATP respectively.

Results: These apparent Z spectra not only clearly indicated the interactions among 31P metabolites, but also suggested that signal amplification and acquisition acceleration could be achieved for individual metabolites (~several mM) by indirectly detecting the bulk 31P signal (~20 mM).

Impact: This study demonstrates that 31P-CEST technique enables the detection of individual metabolites (several mM) by indirectly detecting the bulk 31P signal (~20 mM), indicating the potential of 31P-CEST-MRI for accelerating acquisition and enhancing sensitivity by removing the spectral dimension.

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Keywords