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Abstract #2313

Phenotypic and Genetic Insights into Brain Perfusion Using Arterial Spin Labeling in UK Biobank

Xinyi Xu1,2, Aurea B. Martins-Bach1, Lloyd T. Elliott3, Fidel Alfaro-Almagro1, Gwenaëlle Douaud1, Soojin Lee1, Cristiana Tisca1, Mingyang Li2, Stephen M. Smith1, Karla L. Miller1, Dan Wu2, and Thomas W. Okell1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada

Synopsis

Keywords: Arterial Spin Labelling, Neuroscience, Genetics; Cerebral Blood Flow; Arterial Transit Time; UK Biobank; Alcohol; Hypertension; Population Study

Motivation: Identifying non-invasive brain health markers is essential for tracking neurological risk and therapeutic responses. Arterial Spin Labeling (ASL) shows promise in detecting perfusion changes linked to neurological and psychiatric conditions.

Goal(s): To examine ASL-derived perfusion markers within the large cohort, UK Biobank, focusing on associations with lifestyle, cardiovascular, and genetic factors.

Approach: ASL data from 7,157 participants were analyzed for phenotypic and genetic correlations with cerebral blood flow and arterial transit time, using voxelwise, mediation, and genome-wide association studies (GWAS).

Results: Significant associations were identidied with 155 phenotypes, including alcohol use and hypertension. GWAS identified specific gene variants uniquely relatied to ASL.

Impact: This study highlights ASL-derived measures as valuable indicators of brain health, linking them to lifestyle, cardiovascular, and genetic factors. ASL's potential for population-level monitoring offers insights for early detection and intervention strategies in neurological health, improving patient outcomes.

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Keywords