Keywords: Arterial Spin Labelling, Neuroscience, Genetics; Cerebral Blood Flow; Arterial Transit Time; UK Biobank; Alcohol; Hypertension; Population Study
Motivation: Identifying non-invasive brain health markers is essential for tracking neurological risk and therapeutic responses. Arterial Spin Labeling (ASL) shows promise in detecting perfusion changes linked to neurological and psychiatric conditions.
Goal(s): To examine ASL-derived perfusion markers within the large cohort, UK Biobank, focusing on associations with lifestyle, cardiovascular, and genetic factors.
Approach: ASL data from 7,157 participants were analyzed for phenotypic and genetic correlations with cerebral blood flow and arterial transit time, using voxelwise, mediation, and genome-wide association studies (GWAS).
Results: Significant associations were identidied with 155 phenotypes, including alcohol use and hypertension. GWAS identified specific gene variants uniquely relatied to ASL.
Impact: This study highlights ASL-derived measures as valuable indicators of brain health, linking them to lifestyle, cardiovascular, and genetic factors. ASL's potential for population-level monitoring offers insights for early detection and intervention strategies in neurological health, improving patient outcomes.
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