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Abstract #2316

Dynamic Susceptibility Contrast MRI and Arterial Spin Labeling reveals blood volume dependence of BOLD-based Cerebrovascular Reactivity

Gabriel Hoffmann1,2, Lena Schmitzer1, Jan Kufer1, Franziska Richter1, Claus Zimmer1,2, Jens Göttler1, Stephan Kaczmarz1,2,3, and Christine Preibisch1,2,4
1School of Medicine and Health, Institute for Neuroradiology, Technical University of Munich, Munich, Germany, 2School of Medicine and Health, TUM-Neuroimaging Center, Technical University of Munich, Munich, Germany, 3Philips GmbH Market DACH, Hamburg, Germany, 4School of Medicine and Health, Clinic of Neurology, Technical University of Munich, Munich, Germany

Synopsis

Keywords: Perfusion, Brain, Cerebrovascular Reactivity

Motivation: Cerebrovascular reactivity (CVR) measured via BOLD-MRI indicates vascular health but may be biased by cerebral blood volume (CBV), considering that CBV largely differs between grey (GM) and white matter (WM).

Goal(s): This study aimed to evaluate CBV dependency of BOLD-CVR, hypothesizing that BOLD-CVR would exhibit CBV-related differences between GM and WM.

Approach: BOLD-CVR and CBF-CVR data were compared to relative CBV (rCBV) from Dynamic Susceptibility Contrast MRI (3T-MRI). GM-WM differences and correlations between BOLD-CVR and rCBV were assessed. BOLD signal dependence on baseline venous CBVV,0 was simulated.

Results: BOLD-CVR showed significant rCBV dependency, confirming that baseline rCBV significantly affects BOLD-CVR outcomes.

Impact: BOLD-CVR, a promising marker of vascular health, may be biased by CBV. Using pCASL-CBF and DSC-rCBV data and simulations, we revealed the dependency of BOLD-CVR on rCBV. Therefore, CBV should be considered when interpreting CVR assessments, especially in diagnostic applications.

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