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Abstract #2321

Tumor-infiltrating lymphocytes evaluation using quantitative DCE-MRI-based habitat imaging in breast cancer patients: a preliminary study

Ziyi Mao1, Qi Wang1, Peng Sun2, Haifa Liu1, and Hui Liu1
1Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China, 2Clinical&Techinical Support, Philips Healthcare, Beijing, China

Synopsis

Keywords: Perfusion, Cancer, TILs, q-DCE, habitat imaging

Motivation: Tumor-infiltrating lymphocytes (TILs) are highly correlated with the prognosis of tumor treatment. We seek an efficient and noninvasive method for evaluating TILs based on habitat imaging of perfusion MRI.

Goal(s): We investigate whether the quantitative DCE-based habitat imaging could be utilized to assess TILs in breast cancer patients.

Approach: We developed a logistic predictive model utilizing extracted subregion DCE features to assess TILs, leveraging tumor spatial heterogeneity.

Results: Significant perfusion differences exist between the low and medium-high TILs groups. The predictive model distinguishes the two groups with an AUC of 0.671, sensitivity of 0.571, and specificity of 0.75.

Impact: This study indicates that quantitative DCE-based habitat imaging holds potential for the assessment of TILs in breast cancer.

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