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Abstract #2325

Spatiotemporal variation of the negative hemodynamic response function along the cortical surface of the primary visual cortex in human brain

Artemy Vinogradov1, Nooshin J. Fesharaki1, Minkyu Jung1, and JungHwan Kim1
1Neurosurgery, UTHealth Houston, Houston, TX, United States

Synopsis

Keywords: fMRI Analysis, fMRI Analysis, Hemodynamic Response Function

Motivation: There is limited understanding of the detailed dynamics of the negative BOLD response (NBR).

Goal(s): To investigate changes in NBR dynamics relative to cortical distance from the stimulus representation (SR) on the contralateral side and NBR dynamics on the ipsilateral side.

Approach: Using a unilateral visual stimulus, we measured the nHRFs (NBR evoked by a brief stimulus) and performed distance analysis along the cortical surface to characterize changes of the nHRF dynamics.

Results: Dynamics of the nHRF varies with increasing distance from the SR. Three types of nHRFs are observed with varying proportions with distance from the SR.

Impact: An evolution of nHRF dynamics is apparent with distance from the SR. Different types of nHRFs are found, indicating more complex dynamics of the nHRF.

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Keywords