Keywords: Mesoscale: columns and layers, fMRI Acquisition
Motivation: Conventional T2*-weighted BOLD fMRI based on EPI sequence is limited by geometric distortions and poor localization specificity, necessitating the development of alternative imaging methods.
Goal(s): To develop a high-resolution, high-SNR, distortion-free non-BOLD fMRI method and validate its feasibility for task-based fMRI.
Approach: Developing a 3D bSSFP sequence with 2D-CAIPI acceleration to acquire sub-millimetre resolution functional images, allowing comparison with BOLD fMRI.
Results: Task-based bSSFP fMRI reveals a reasonable activation pattern, different from that of BOLD fMRI.
Impact: This study integrates 3D bSSFP acquisition into task-based fMRI, employing 2D-CAIPI acceleration to enhance acquisition speed, and conducts a comparative analysis with BOLD fMRI, highlighting the superior spatial localization accuracy of bSSFP.
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