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Abstract #2328

CAIPI accelerated 3D bSSFP for laminar fMRI at 7T

Zhanyan Zhang1,2,3, Yifei Wang1,3, Chen Liu1,3, Qiong Zhang4, Jing An4, Chencan Qian1,3, Peng Zhang1,3, and Zihao Zhang1,2,3
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China, 3University of Chinese Academy of Sciences, Beijing, China, 4DL, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

Synopsis

Keywords: Mesoscale: columns and layers, fMRI Acquisition

Motivation: Conventional T2*-weighted BOLD fMRI based on EPI sequence is limited by geometric distortions and poor localization specificity, necessitating the development of alternative imaging methods.

Goal(s): To develop a high-resolution, high-SNR, distortion-free non-BOLD fMRI method and validate its feasibility for task-based fMRI.

Approach: Developing a 3D bSSFP sequence with 2D-CAIPI acceleration to acquire sub-millimetre resolution functional images, allowing comparison with BOLD fMRI.

Results: Task-based bSSFP fMRI reveals a reasonable activation pattern, different from that of BOLD fMRI.

Impact: This study integrates 3D bSSFP acquisition into task-based fMRI, employing 2D-CAIPI acceleration to enhance acquisition speed, and conducts a comparative analysis with BOLD fMRI, highlighting the superior spatial localization accuracy of bSSFP.

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