Abstract #2332

Cortical layer-dependent response changes in M1 in Parkinson's Disease: a submillimeter 7T fMRI study with 3D passband balanced SSFP

Yifei Wang^1,2, Donning Su^3,4, Rui Yan^3,4, Lasse Knudsen⁵, Ning Wei⁶, Jing An⁷, Tao Feng^3,4, and Peng Zhang^1,2

¹State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, BeiJing, China, ²University of Chinese Academy of Sciences, BeiJing, China, ³Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, BeiJing, China, ⁴China National Clinical Research Center for Neurological Diseases, BeiJing, China, ⁵Sino-Danish Center for Education and Research (SDC), University of Chinese Academy of Sciences, BeiJing, China, ⁶Tiantan Neuroimaging Center of Excellence,Beijing Tiantan Hospital, Capital Medical University, BeiJing, China, ⁷Siemens Shenzhen Magnetic Resonance Ltd, BeiJing, China

Synopsis

Keywords: Mesoscale: columns and layers, Parkinson's Disease, primary motor cortex (M1)

Motivation: How Parkinson's disease (PD) affects the neural circuitry in the primary motor cortex (M1).

Goal(s): Investigate laminar response changes in the M1 at early and advanced stages of PD.

Approach: A 3D passband bSSFP sequence at 7 Tesla was used to investigate layer-specific functional activity in the M1 of two PD patients during a hand grasping task.

Results: Compared to the less affected hand, the more affected hand movement of the early-stage patient showed stronger activation in the superficial layers of M1 in the contralateral hemisphere; while the advanced-stage patient showed overall weaker activations.

Impact: These findings provide clues to to dysfunctions and progression of PD in the M1 microcircuitry, showscasing that laminar fMRI is a valuable tool for investigating the mechanisms underlying neurodegenerative disorders.

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