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Abstract #2334

Investigating the Impact of Spatially Selective Signal Suppression on BOLD fMRI Reliability

Yongli He1, Luis Hernandez-Garcia2, Douglas C. Noll2, and Jon-Fredrik Nielsen2
1fMRI Laboratory and Applied Physics, University of Michigan, Ann Arbor, MI, United States, 2fMRI Laboratory, Department of Radiology and Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: fMRI Acquisition, Acquisition Methods, rFOV Imaging

Motivation: Reduced field-of-view (rFOV) imaging can improve spatio-temporal resolution in functional MRI (fMRI), but its impact on activation detection has not (to our knowledge) been examined.

Goal(s): To design a short (6ms) outer-volume-suppression (OVS) RF pulse for rFOV fMRI, and investigate its impact on the sensitivity and reliability of BOLD fMRI activation.

Approach: We obtained accelerated (R=7.5) BOLD data during four repetitions of a block finger-tapping task, with and without OVS. We assessed test-retest reliability of the activation maps using receiver-operating-characteristic (ROC) analysis.

Results: The 6 ms OVS pulse somewhat lowers sensitivity to motor cortex BOLD activation, but somewhat improves test-retest reliability.

Impact: Outer-volume suppressed fMRI can produce reliable activation maps, and may be a promising candidate for high-resolution (e.g., layer-specific) fMRI.

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