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Abstract #2338

Functional imaging of hippocampal layers using VASO on the Next Generation (NexGen) 7T

Suvi Häkkinen1, Alexander Beckett1,2, Erica Walker1,2, Renzo Huber3, and David A Feinberg1,2
1Helen Wills Neuroscience Institute, Berkeley, CA, United States, 2Advanced MRI Technologies, Sebastopol, CA, United States, 3NIH, Bethesda, MD, United States

Synopsis

Keywords: Mesoscale: columns and layers, fMRI Acquisition, VASO, hippocampus

Motivation: Imaging hippocampal activity is challenging due to its anatomical location deep in the brain, high physiological noise, and sensitivity to individual vasculature.

Goal(s): Optimize the VASO imaging sequence on the NexGen 7T scanner at sub-millimeter resolution to assess layer-specific VASO patterns using an established autobiographical memory task.

Approach: Measure activation of the right hippocampus in three subjects, and compare layer profiles based on VASO and BOLD from the same acquisition, per hippocampal subfield.

Results: Hippocampal VASO activation was observed in all subjects. Depth-related differences between VASO and BOLD were in line with lesser venous bias in VASO.

Impact: Hippocampal fMRI using VASO contrast allows mapping layer function with high accuracy, made possible by optimization for the NexGen 7T scanner. Spatial accuracy and venous biases are a central concern for studies developing mechanistic models for hippocampal circuits.

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Keywords