Keywords: Mesoscale: columns and layers, fMRI Acquisition, VASO, hippocampus
Motivation: Imaging hippocampal activity is challenging due to its anatomical location deep in the brain, high physiological noise, and sensitivity to individual vasculature.
Goal(s): Optimize the VASO imaging sequence on the NexGen 7T scanner at sub-millimeter resolution to assess layer-specific VASO patterns using an established autobiographical memory task.
Approach: Measure activation of the right hippocampus in three subjects, and compare layer profiles based on VASO and BOLD from the same acquisition, per hippocampal subfield.
Results: Hippocampal VASO activation was observed in all subjects. Depth-related differences between VASO and BOLD were in line with lesser venous bias in VASO.
Impact: Hippocampal fMRI using VASO contrast allows mapping layer function with high accuracy, made possible by optimization for the NexGen 7T scanner. Spatial accuracy and venous biases are a central concern for studies developing mechanistic models for hippocampal circuits.
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