Abstract #2359

Assessment of molecular and pH-weighted signal changes in chronic ischemic stroke using CEST MRI at 3T

Jianpan Huang^1,2, Mandy Yuen Man Chan^2,3, Yi Zhang⁴, Gary Kui Kai Lau^2,3, and Kannie Wai Yan Chan^5,6,7,8

¹Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, ²Tam Wing Fan Neuroimaging Research Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, ³Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, ⁴Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ⁵Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ⁶Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, China, ⁸Tung Biomedical Science Centre, City University of Hong Kong, Hong Kong, China

Synopsis

Keywords: Stroke, Stroke, CEST / APT / NOE

Motivation: The sensitivity of CEST MRI in imaging the molecular and pH-weighted signal changes of chronic ischemic stroke remains largely unexplored.

Goal(s): The goal of this study is to study the changes of multiple CEST contrasts and amide and amine concentration independent detection (AACID) signal in human brains of chronic ischemic stroke.

Approach: CEST scans at 3T were conducted for 17 healthy controls and 8 patients with chronic ischemic stroke. Multiple CEST contrasts and AACID signal were extracted for comparison.

Results: The brain of chronic ischemic stroke exhibited significantly reduced amide, rNOE, and MT signals, along with an enhanced AACID signal.

Impact: Chronic ischemic stroke brains exhibited decreased amide, rNOE, and MT signals, indicating reductions in proteins and lipids, along with an increased AACID signal suggesting a lower pH level. CEST MRI can monitor the prognosis of ischemic stroke in clinical settings.

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