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Abstract #2372

The Application of New Models WMTI and MAPL in Assessing White Matter Microstructural Damage in Non-basal Ganglia Subcortical Ischemic Stroke

Haorui Wan1, Houming Su1, Yuanhao Li1, and Wenzhen Zhu1
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Synopsis

Keywords: Stroke, Stroke

Motivation: Despite the prevalent use of DTI and DKI in assessing ischemic stroke, these methods fall short in accurately characterizing non-Gaussian diffusion behavior in brain tissues, often leading to an underestimation of microstructural changes.

Goal(s): evaluate the feasibility of the models WMTI and MAPL for the quantitative detection of microstructural changes in brain tissue during ischemic stroke

Approach: This study introduced the model WMTI and MAPL to enhance the assessment of white matter microstructural damage in non-basal ganglia subcortical ischemic stroke

Results: The study proved that the diffusion models WMTI and MAPL are feasible for assessing ischemic stroke.

Impact: Compared to traditional diffusion models DTI and DKI, the novel diffusion model MAPL exhibits higher sensitivity in describing changes in brain tissue microstructure. Additionally, changes observed during follow-up are positively correlated with NIHSS changes, making it a potential biomarker for estimating brain injury in ischemic stroke.

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Keywords