Abstract #2378

Correction of receiver profile bias in brain tumors using T1 maps for accurate water content mapping

Dennis C. Thomas^1,2,3,4, Mariem Ghazouani¹, Andrei Manzhurtsev¹, Elke Hattingen^1,2,3,4, and Katharina J. Wenger^1,2,3,4

¹Goethe University Frankfurt, University Hospital Frankfurt, Institute of Neuroradiology, Frankfurt am Main, Germany, ²University Cancer Center Frankfurt (UCT), Frankfurt, Frankfurt am Main, Germany, ³Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany, ⁴German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), Heidelberg, Germany

Synopsis

Keywords: Tumors (Pre-Treatment), Tumors, water content mapping, bias field correction

Motivation: Current methods for water content (H₂O)-mapping in brain tumors (BT) lead to an underestimation of H₂O due to the imperfect bias field profile estimation.

Goal(s): Using T1-maps for a more accurate bias field profile estimation in BT patients.

Approach: Bias field-maps were obtained from T1-maps and used to correct for the bias in the conventional bias field correction approach. The proposed method was tested in 24 patients with suspected intra-axial BT.

Results: The proposed method led to a significant increase in the measured water content in comparison to the conventional method in larger tumors, but not in small tumors.

Impact: Current methods for H₂O-mapping in brain tumors have bias field estimation inaccuracies. Here, T1-maps were used to correct for these inaccuracies and results evaluated in 24 patients. Large tumors had a significant increase in water content after the proposed correction.

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