Abstract #2382

Targeted BBB Opening with Golay-coded Ultrasound to Enhance Treatment of Glioblastoma

Taekyu Jang^1,2,3, Hyochul Lee^1,2,3,4, Seoyun Chang⁵, Okkyu Park^3,6, Seung Hong Choi^3,6,7,8, Jinhyoung Park^5,9, and Roh-Eul Yoo^3,7

¹Cancer Research Institute, Seoul National University, Seoul, Korea, Republic of, ²Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea, Republic of, ³Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, ⁴Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, Korea, Republic of, ⁵Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, ⁶Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea, Republic of, ⁷Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁸School of Transdisciplinary Innovations, Seoul National University, Seoul, Korea, Republic of, ⁹Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: Tumors (Post-Treatment), Focused Ultrasound, Blood-Brain Barrier

Motivation: The blood-brain barrier is a critical structure that protects neural tissue in the brain. However, it also presents a significant obstacle to therapeutic drugs reaching brain tumors.

Goal(s): Our goal was to apply focused ultrasound precisely on tumor regions to increase drug delivery into the tumor while minimizing off-target effects in surrounding healthy tissue.

Approach: We used Golay-coded ultrasound with contrast-enhanced MR imaging to assess BBB opening in normal mice and to target tumor sites in GBM models for evaluating treatment efficacy.

Results: The Golay-coded group showed more consistent BBB opening regions, and tumor experiments also demonstrated the highest therapeutic efficacy.

Impact: Golay-coded ultrasound enables precise BBB opening in targeted regions and can be a foundational adjunct technology to improve drug delivery efficiency, which could potentially be applied clinically to treat various brain diseases.

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