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Abstract #2387

Impairments in Functional Connectivity and Glymphatic System in Breast Cancer Patients Undergoing Treatment

Quanquan Gu1, Leonardo Tang1, Nilofar Vafaie2, Claire Gong3, Philip Kragel4, Jinbing Bai5, and Hui Mao1
1Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 2Psychology, Emory University, Atlanta, GA, United States, 3Emory College of Arts and Sciences, Emory University, Atlanta, GA, United States, 4Psychology, Emory University, Atlanta, Georgia, 5Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States

Synopsis

Keywords: Tumors (Post-Treatment), Functional Connectivity, glymphatic system

Motivation: Cancer patients may have declined glymphatic function and functional connectivity due to treatment effcts.

Goal(s): Aiming to explore the association between glymphatic dysfunction and DMN-based FC pattern in treated breast cancer (BC) patients.

Approach: We combined seed-based analysis of DMN and DTI data-derived index of diffusivity along the perivascular space (ALPS-index) to explore alterations in FC and glymphatic function. Pearson’s correlation was performed to examine the association between altered DMN-based FC and ALPS-index in BC group.

Results: Our study demonstrated altered DMN-based FC and declined ALPS-index in BC patients. Lower right-hemisphere ALPS-index in BC patients was linked to higher posterior cingulate cortex-precuneus FC.

Impact: Altered DMN-based functional connectivity and bilateral ALPS-index, as well as the negative correlation between elevated posterior cingulate cortex-precuneus connectivity and ALPS-index in BC, indicate a potential mechanism overcoming glymphatic dysfunction by enhancing functional interactions.

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