Meeting Banner
Abstract #2390

Longitudinal assessment of changes in brain metabolism in the normal-appearing white matter of patients with lower-grade glioma.

Yiqi Liu1, Tracy Luks1, Adam Autry1, Sana Vaziri1, Lina Cheung1, Janine Lupo1, Nancy Ann Oberheim Bush2, Susan Chang 2, Javier Villanueva-Meyer1, and Yan Li1
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Neurological Surgery, UCSF, San Francisco, CA, United States

Synopsis

Keywords: Tumors (Post-Treatment), Spectroscopy

Motivation: Metabolic characteristics related to treatment in patients with Lower-grade gliomas (LrGG) can improve survival outcomes and quality of life.

Goal(s): The goal of this study was to evaluate longitudinal changes in metabolite ratios of pre-treated LrGG patients who received no further treatment.

Approach: The study uses quantified metabolite ratios obtained from 3D MRSI in an existing LrGG cohort and statistically compared those ratios across different pre-treatment groups and baseline.

Results: Although all treatment groups show no statistically significant differences at 3 time points, two treatment groups display significant changes of metabolite ratios at 6 months and past 24 months.

Impact: Results of this study can provide insight into if different treatments can impact a patient’s neurocognitive function that is tied with metabolite profile. The finding can also provide suggestions on when re-treatment is recommended for patients with LrGG.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords