Abstract #2411

Differences in Early Brain Structure Between Infants with Normal and Abnormal Prognosis in External Hydrocephalus

huifang zhao¹, yuxin sun², yidan yin², xianjun li², miaomiao wang², congcong liu², jian yang², and chao jin²

¹Department of Radiology, 1.Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China 2.Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence, Xi’an, China 3.Xi’an Key Laboratory of Medical Computational Imaging, Xi’an, China, Xi’an, China, ²1.Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China 2.Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence, Xi’an, China 3.Xi’an Key Laboratory of Medical Computational Imaging, Xi’an, China, Xi’an, China

Synopsis

Keywords: Neuro, Pediatric

Motivation: The study seeks to identify early brain structure differences in infants with external hydrocephalus (EH) to better predict and address developmental delays and adverse outcomes.

Goal(s): To determine specific cortical differences using MRI that correlate with benign or poor prognoses in infants with EH.

Approach: Utilized cortical reconstruction and quantification through MRI imaging to compare cortical thickness, surface area, volume, and curvature in infants with benign versus poor outcomes.

Results: Infants with poor prognoses showed reduced cortical volume and surface area in regions vital for motor and language functions compared to those with benign outcomes.

Impact: Early MRI detection of cortical differences in EH infants can guide interventions to prevent developmental delays.

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