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Abstract #2416

Hippocampal morphometry is altered in children with congenital heart disease

Barat Gal-Er1, Alexandra F. Bonthrone1, Mirthe E.M van der Meijden1, Andrew T.M Chew1, Chiara Casella1,2, Yannick Brackenier1,3, Michela Cleri3, Pierluigi Di Cio3, Alexia Elgoff1, Kuberan Pushparajah4,5, John Simpson4,5, Mary A. Rutherford1, A. David Edwards1, Shaihan Malik1,3, Lucilio Cordero-Grande1,3,6, Joseph V. Hajnal1,3, Chiara Nosarti1,7, Jonathan O’Muircheartaigh1,2, and Serena J. Counsell1
1Early Life Imaging Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, 3Imaging Physics & Engineering Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 4Department of Cardiovascular Imaging, King's College London, London, United Kingdom, 5Department of Fetal and Paediatric Cardiology, Evelina London Children’s Hospital, London, United Kingdom, 6Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, ISCIII, Madrid, Spain, 7Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Synopsis

Keywords: Neuro, Brain, Congenital heart disease, Morphometry, Hippocampus

Motivation: Congenital heart disease (CHD) is associated with altered brain development, as well as an increased prevalence of neurodevelopmental impairments. The hippocampus in particular is hypothesised to be altered in individuals with CHD.

Goal(s): We aimed to assess hippocampal subfield morphometry in children with CHD and controls.

Approach: We compared hippocampal morphometric measures between children with CHD (n=20) and controls (n=104) aged 7-8 years using HippUnfold.

Results: Children with CHD demonstrated bilateral smaller total hippocampal, cornu ammonis 1, dentate gyrus, and stratum radiatum and lacunosum moleculare volumes (PFDR < 0.05) and reductions in gyrification at the vertex-wise level (PFWE < 0.025).

Impact: This study extends previous work showing reduced hippocampal volume in this population by identifying reduced hippocampal gyrification and subfield volume in children with CHD. Altered hippocampal development may be a key determinant of neurodevelopmental impairments observed in children with CHD.

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Abstract

Keywords