Abstract #2421

Diffusion Kurtosis Imaging and Arterial Spin Labeling MRI for Post-Contrast Acute Kidney Injury in Rats with Subclinical Acute Kidney Injury

Hongtao Yuan¹, Shuangshuang Xie², Jinxia Zhu³, Bernd Kuehn ⁴, Robert Grimm⁴, and Wen Shen⁵

¹The First Central Clinical School, Tianjin Medical University, Tianjin, China, ²Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ³MR Research Collaboration, Siemens Healthineers, Beijing, China, Tianjin, China, ⁴MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany, Tianjin, China, ⁵Department of Radiology, Tianjin First Central Hospital, Tianjin Institute of Imaging Medicine, Tianjin, China, Tianjin, China

Synopsis

Keywords: Kidney, Contrast Agents, Post-contrast acute kidney injury

Motivation: Subclinical acute kidney injury (sAKI) was a latent pre-clinical status and might make it more vulnerable to kidney injury factors.

Goal(s): The aim of this study was to investigate post-contrast acute kidney injury (PC-AKI) progression of sAKI rats and verify fMRI as an effective tool to detect renal injury.

Approach: H&E staining, quantitative PCR and immunohistochemical staining of hypoxia inducible factor-1α was used to evaluate renal hypoxia. Diffusion kurtosis imaging and arterial spin labeling MRI was applied to during PC-AKI.

Results: The sAKI rats suffered more serious renal injury and delayed recovery during PC-AKI. MRI parameters had a good relationship with pathological changes.

Impact: Risk of PC-AKI in sAKI status should be reconsidered. Multiparameter MRI is an effective tool to detect renal injury.

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