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Abstract #2424

A Study on Predicting Individual Kidney Function Using Renal Blood Flow Weighted eGFR Using Arterial Spin Labeling MRI

Zhiyong Lin1, Yuxi Li2, Jinxia Zhu3, and Jianxing Qiu1
1Department of Radiology, Peking University First Hospital, Beijing, China, 2Department of Cardiology, Peking University First Hospital, Beijing, China, 3MR Collaboration, Siemens Healthcare, Ltd., Beijing, China

Synopsis

Keywords: Task/Intervention Based fMRI, Arterial spin labelling, renal dysfunction; glomerular filtration rate; renal blood flow

Motivation: Renal artery stenosis(RAS) often leads to hypertension and renal insufficiency, yet diagnosing Individual renal function accurately is challenging.

Goal(s): To develop an renal blood flow(RBF) weighted estimated glomerular filtration rate (eGFR) method using arterial spin labeling MRI(ASL-MRI) for better Individual renal function assessment.

Approach: 32 patients with RAS underwent ASL-MRI; RBF-weighted eGFR was calculated and compared to radionuclide GFR.

Results: The RBF-weighted eGFR based on ASL-MRI had a high consistency with the GFR values of the radionuclide renal dynamic imaging, and a high diagnostic efficacy in the differential diagnosis of renal dysfunction.

Impact: This novel method improves renal function assessment in RAS patients, potentially guiding clinical decisions and facilitating further research into renal disease management.

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Keywords