Keywords: Task/Intervention Based fMRI, Arterial spin labelling, renal dysfunction; glomerular filtration rate; renal blood flow
Motivation: Renal artery stenosis(RAS) often leads to hypertension and renal insufficiency, yet diagnosing Individual renal function accurately is challenging.
Goal(s): To develop an renal blood flow(RBF) weighted estimated glomerular filtration rate (eGFR) method using arterial spin labeling MRI(ASL-MRI) for better Individual renal function assessment.
Approach: 32 patients with RAS underwent ASL-MRI; RBF-weighted eGFR was calculated and compared to radionuclide GFR.
Results: The RBF-weighted eGFR based on ASL-MRI had a high consistency with the GFR values of the radionuclide renal dynamic imaging, and a high diagnostic efficacy in the differential diagnosis of renal dysfunction.
Impact: This novel method improves renal function assessment in RAS patients, potentially guiding clinical decisions and facilitating further research into renal disease management.
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