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Abstract #2435

Glomerular Filtration Rate and Renal Plasma Flow Measurement from DCE-MRI with Population- Arterial Input Function and a One-Compartment Model

Xin Mu1, Mira Liu1, Jeff L. Zhang2, Haitham Al-Mubarak3, Paul Kennedy1, Philip Robson1, Jordan Cuevas1, Bernd Kuhn4, Ketan Badani5, Bachir Taouli1,6, Sara Lewis1, and Octavia Bane1,7
1Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2ShanghaiTech University, shanghai, China, 3Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Siemens Healthcare, Erlangen, Germany, 5Urology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 6BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 7BioMedical Engineering and Imaging Institute, Mount Sinai Hospital, New York, NY, United States

Synopsis

Keywords: Kidney, Kidney, renal pharmacokinetic model

Motivation: DCE-MRI is promising for measuring single-kidney GFR and RPF, but the complex post-processing poses challenges to its clinical application.

Goal(s): We introduce a streamlined method that combines population arterial input function (pAIF) with a whole-kidney model to simplify eGFR and RPF calculations.

Approach: In a prospective, single-center study in 43 patients with renal masses undergoing 51 MRIs, we evaluated the correlation and agreement of eGFR and RPF measurements from pAIF against traditional individual AIF (iAIF) methods and reference serum-derived GFR and ASL-derived RPF.

Results: Our pAIF method demonstrates superior correlation and agreement with clinical reference values compared to iAIF.

Impact: Noninvasive assessment of single-kidney function is crucial for surgical planning and guiding appropriate treatment. The combination of pAIF and whole-kidney model offers a promising and streamlined method for evaluating single-kidney function by providing key parameters such as eGFR and RPF.

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Keywords