Abstract #2450

Dixon water-fat separation for 3D diffusion-prepared gradient echo at 3T

Yannik Ott^1,2, Sarah McElroy^1,3, Raphael Tomi-Tricot^1,4, Omar Darwish², Shawna Kinsella⁵, Sami Jelijeli⁵, Vicky Goh^6,7, and Radhouene Neji¹

¹Imaging physics and engineering research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany, ³MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, ⁴Siemens Healthcare SAS, Courbvoie, France, ⁵PET Centre, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁶Cancer imaging research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁷Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Prostate, Prostate

Motivation: Fat suppression is an important aspect in diffusion imaging. While Dixon water-fat separation has been adopted in a wide range of MRI sequences, its use in diffusion imaging remains limited.

Goal(s): To develop a sequence that enables 3D diffusion imaging with Dixon water-fat separation.

Approach: A 3D diffusion-prepared gradient echo sequence is combined with bipolar two-point Dixon readouts and in-phase 2D navigator echoes for inter-shot phase correction, followed by a water-fat Dixon separation. Prostate diffusion imaging scans were performed with the proposed sequence in two healthy volunteers.

Results: The proposed sequence shows excellent fat suppression for 3D diffusion imaging in the prostate.

Impact: This work introduces an approach for water-fat separation in 3D diffusion imaging, thereby enabling excellent fat suppression.

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