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Abstract #2458

Plus-minus CrCEST provides higher temporal resolution mapping of skeletal muscular creatine

Ritambhar Burman1, Jennifer Valley1, Yuxi Pang1, and Puneet Bagga1
1Radiology, St. Jude Children's Research Hospital, Memphis, TN, United States

Synopsis

Keywords: CEST / APT / NOE, CEST & MT

Motivation: CrCEST MRI is valuable for mapping creatine recovery in muscle but has lower temporal resolution than the gold-standard 31P-MRS, leading to discrepancies in recovery time measurements.

Goal(s): To improve CrCEST temporal resolution and reduce discrepancies in τCrCEST values with 31P-MRS

Approach: A 26-year-old subject’s calf muscles were scanned using the traditional CrCEST and the proposed Plus-Minus CrCEST approach, which uses ±1.8 ppm saturation frequency offsets to achieve faster imaging.

Results: Plus-Minus CrCEST increased temporal resolution threefold, halved τCrCEST values, and aligned closely with 31P-MRS measurements, suggesting enhanced applicability in metabolic studies.

Impact: The Plus-Minus CrCEST approach achieves a threefold increase in temporal resolution for creatine recovery mapping in skeletal muscle, aligning τCrCEST values with 31P-MRS and broadening CrCEST's potential for advanced metabolic and physiological research applications.

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Keywords