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Abstract #2461

Metabolic CEST MR imaging of glucosamine uptake in brain tumors

Yaniv Yosha1, Michal Rivlin2, Gil Navon3, and Or Perlman2,4
1Electrical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 3Chemistry, Tel Aviv University, Tel Aviv, Israel, 4Sagol School of Neuroscience, Tel Aviv Univercity, Tel Aviv, Israel

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE

Motivation: The CEST signal of glucosamine (GlcN), a non-toxic food supplement was previously demonstrated in breast tumors and mouse brains.

Goal(s): To investigate GlcN uptake and efficacy in detecting brain tumors.

Approach: CEST MRI scans (7T) were performed in tumor-bearing mice (n=6) before and after GlcN injection. Data were analyzed using the magnetization transfer ratio asymmetry (MTRasym) metric.

Results: Tumor regions presented signal enhancement compared to the contralateral tissue. The area under the MTRasym curve (1-2.2 ppm) was significantly higher at the tumor (P<0.05).

Impact: This is the first study that examines the use of GlcN for brain tumor imaging. Given its low toxicity and transport capabilities across the blood-brain barrier (BBB), GlcN may be used as a nonmetallic contrast agent for evaluating brain malignancies.

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