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Abstract #2466

Turnkey Preclinical CEST-MRF for Bruker ParaVision 360

David E Korenchan1, Saaussan Madi2, Nikita Vladimirov3, Todd Sasser2, Tim Wokrina2, Or Perlman3, and Christian T. Farrar1
1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Bruker BioSpin, Billerica, MA, United States, 3Bio-Medical Engineering, Tel Aviv University, Tel Aviv, Israel

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE, Preclinical imaging; Pulse sequence; Image reconstruction; MR fingerprinting

Motivation: High-resolution molecular imaging with chemical exchange saturation transfer (CEST) and magnetic resonance fingerprinting (MRF) is difficult to implement and analyze, even for preclinical studies. Making preclinical CEST-MRF easier would spur rapid development.

Goal(s): We aimed to develop a Bruker ParaVision 360 method and corresponding processing pipeline to easily design a CEST-MRF experiment and quickly evaluate the results.

Approach: The sequence includes a .txt read-in feature for CEST-MRF parameter specification. The MATLAB processing pipeline features a graphical user interface for easy image processing and statistics.

Results: The imaging method and processing pipeline are available on GitHub and make CEST-MRF imaging easy to implement.

Impact: The Bruker ParaVision 360 imaging method and processing pipeline we developed is publicly available and will facilitate CEST-MRF imaging development by making experiments easy to customize and analyze, spurring more rapid CEST-MRF development towards clinical imaging.

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