Abstract #2471

Study of flow dynamics in realistic aneurysm phantom with 4D flow MRI, Optical Transmission (OT), and Magnetic Particle Imaging (MPI)

Teresa Reichl¹, Ali el Ahmar², Thomas Kampf³, Johanna Günther¹, Martin A. Rückert¹, Thorsten A. Bley⁴, Stefan Herz^4,5, Volker C. Behr¹, Susanne Schnell^2,6, Patrick Winter^2,6, and Patrick Vogel^1,7

¹Department of Experimental Physics 5 (Biophysics), Julius-Maximilians University Würzburg, Würzburg, Germany, ²Department of Medical Physics, University of Greifswald, Greifswald, Germany, ³Department of Diagnostics and Interventional Neuroradiology, University Hospital Würzburg, Würzburg, Germany, ⁴Department of Diagnostics and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ⁵Radiologie Augsburg Friedberg, Augsburg, Germany, ⁶Department of Radiology, Northwestern University, Chicago, IL, United States, ⁷Pure Devices GmbH, Rimpar, Germany

Synopsis

Keywords: Velocity/Flow, Velocity & Flow, Magnetic Particle Imaging, 4D flow MRI, Optical transmission, aneurysm, phantom

Motivation: The risk of aneurysm rupture and treatment complications can lead to life-threatening bleeding. The flow dynamics may play an important role in understanding aneurysm formation and rupture.

Goal(s): Visualization of flow dynamics in a realistic aneurysm phantom with 4D flow MRI, Optical transmission (OT), and Magnetic Particle Imaging (MPI) and investigation of the influence of vessel curvature on flow dynamics.

Approach: Measuring the flow dynamics in a 3D-printed aneurysm phantom using 4D flow MRI, OT and MPI.

Results: Flow dynamics measured with 4D flow MRI, OT, and MPI show good agreement, and vessel curvature was found to strongly influence flow dynamics in aneurysms.

Impact: Three modalities, 4D flow MRI, OT and MPI were used to visualize and compare the flow dynamics in realistic aneurysm phantoms with good agreement. The vessel curvature was found to strongly influence the flow dynamics.

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