Abstract #2474

Characterization of Turbulence and Pressure Gradients in Venous Sinus Stenosis: A Phantom Study using 4D Flow MRI with ICOSA6 Encoding and vWERP-t

Jonas Schollenberger¹, Haider Ali¹, Keerthi Valluru¹, Matthew Amans¹, David Nordsletten², David Saloner¹, and David Marlevi³

¹Department of Radiology & Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, ²Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ³Department of Molecular Medicine and Surgery, karolinska institutet, Solna, Sweden

Synopsis

Keywords: Velocity/Flow, Velocity & Flow, intracranial Pressure estimation

Motivation: Pulsatile tinnitus is related to changes in venous sinus hemodynamics. However, non-invasive quantification of turbulence and resulting irreversible pressure loss remains scarce.

Goal(s): To non-invasively measure turbulence-driven pressure gradients in venous sinus stenosis.

Approach: Pressure gradients were measured in a patient-specific flow phantom of venous sinus stenosis using 4D Flow MRI with ICOSA6 encoding in combination with the virtual work-energy relative pressure method (vWERP-t) and validated against catheter-based manometry.

Results: The inclusion of turbulent dissipation had distinct impact on estimated relative pressures. vWERP-t derived pressures agreed with reference manometry but results directly depended on resolution and flow rate.

Impact: This work demonstrates the feasibility of measuring turbulence-driven pressure gradients in venous sinus flows non-invasively, laying the groundwork for future in-vivo studies to investigate the relationship between pulsatile tinnitus and venous sinus hemodynamics.

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