Abstract #2479

Comparison of MR-based oximetry for whole-brain oxygen extraction fraction in adults with sickle cell disease

Yu-Hsien Chen¹, Pei-Hsin Wu¹, Sangeev Chawla², Farzana Sayani³, J. Eric Russell³, Felix W Wehrli⁴, and S. Ali Nabavizadeh²

¹Department of Electrical Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, ²Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Oxygenation, Oxygenation

Motivation: OEF as a biomarker requires SvO₂ quantity, which can be estimated via susceptometry-based oximetry (SBO) and T₂-based oximetry (T₂O). SvO₂ presents a 3% bias in T₂O relative to SBO in healthy subjects, while OEF between SBO and T₂O in adults with sickle cell disease (SCD) still needs investigation.

Goal(s): Our goal was to evaluate the systemic bias of SvO₂-dependent quantities between SBO and T₂O in adults with SCD.

Approach: In this study, OxFlow and TRUST sequences were conducted for SvO₂ estimation.

Results: SBO and T₂O yielded a negligible bias in OEF in subjects with SCD.

Impact: SBO and T2O are in good agreement in OEF estimation, in excellent consistence with the trend reported for healthy subjects.

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