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Abstract #2481

Venous oxygenation measurements in the upper arm: reproducibility and sensitivity to a physical challenge

J. Diogo Fernandes1, Koen P.A. Baas1, John C. Wood2,3, Matthan W.A. Caan1, Bart J. Biemond4, and Aart J. Nederveen1
1Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 3Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 4Clinical Hematology, Amsterdam UMC, Amsterdam, Netherlands

Synopsis

Keywords: Arterial Spin Labelling, Blood vessels, Oxygenation

Motivation: TRUST estimates blood oxygenation in the superior sagittal sinus via T2 decay fitting. However, validating the calibration curve—derived from ex-vivo tests on healthy and specific patient samples—is challenging due to the inability to directly sample blood from the sinus.

Goal(s): The goal is to adapt TRUST for T2b arm measurements that can be compared with cephalic vein blood samples.

Approach: TRUST was adapted to the arm veins, allowing for direct comparison with venous blood samples and tracking oxygenation dynamics during exercise.

Results: The modified TRUST sequence successfully measured venous blood T2 in the upper arm, enabling disease-specific calibration curves through direct blood correlation.

Impact: The optimized TRUST sequence enables fast-T2b measurements in upper arm veins, allowing accurate, disease-specific venous calibration curves via a-posteriori blood characteristic correlation. This may improve oxygenation assessment using TRUST in various patient groups, providing a tool to investigate pathological mechanisms.

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Keywords