Keywords: Functional Connectivity, Psychiatric Disorders, Dynamic functional connectivity, Triple Network, White matter functional network, coupling
Motivation: The brain functional alterations in schizophrenia and the impact of antipsychotic medication on brain function remain unclear.
Goal(s): To explore the changes in the triple network and white matter functional networks in patients with schizophrenia, as well as the variations observed during longitudinal follow-up after treatment.
Approach: A sliding window approach was used to analyze the dynamic functional connectivity (FC) of the triple network and white matter, as well as the global coupling between them.
Results: Schizophrenia patients showed alterations in the dynamic FC within networks, as well as in their temporal characteristics, which exhibited dynamic changes over the follow-up period.
Impact: These findings highlight the importance of dynamic FC and functional coupling between the triple network and white matter in the pathogenesis of schizophrenia, which may aid in a better comprehension of the dynamic changes within the disease networks.
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