Keywords: Functional Connectivity, fMRI (resting state), Sleep, resting state fMRI, silent fMRI, Sleep cycle, BOLD, Brain Connectivity, Brain Dynamics
Motivation: Memory consolidation, synaptic pruning, waste-clearance, immune and hormone modulation require neurovascular-sleep dynamics. We evaluate the novel, silent, Looping Star with the aim of capturing the sleep cycle without acoustic-evoked-microarousals.
Goal(s): To demonstrate the spectral fidelity of silent fMRI with Looping Star, and the ability to detect low and high-frequency BOLD spectral features associated with sleep.
Approach: Multi-echo Looping Star was tested in volunteers by synchronizing to their natural sleep cycle. BOLD spectral power between low(<0.1Hz) and high(>0.1Hz) frequency bands was evaluated.
Results: Distinct transitions between awake, drift and sleep are noted, while replicating previously reported spectral correlates of EEG-fMRI of NREM sleep.
Impact: Due to difficulty of simultaneous EEG-fMRI and the acoustic footprint, our understanding of sleep remains limited. Using the silent Looping Star we report sleep, drift and awake-brain hemodynamic activity. Signatures correlate with slow-wave and spindle activity previously reported with EEG-fMRI.
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