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Abstract #2492

Shared and Distinct Alterations in Brain Connectivity and Cognitive Function in Subthreshold and Major Depression

Xinyue Tang1, Pan Chen1, Shuming Zhong1, Guanmao Chen1, Ruoyi Chen1, Wei Cui2, and Ying Wang1
1First Affiliated Hospital of Jinan University, Guangzhou, China, Guangzhou, China, 2GE Healthcare, MR Research, Guangzhou, China

Synopsis

Keywords: Functional Connectivity, fMRI (resting state), Subthreshold depression; Functional connectivity; Brain network; Cognitive function; Major depressive disorder

Motivation: Subthreshold depression (StD) is considered a prodromal stage of major depressive disorder (MDD), which often results in misdiagnosis and delays in proper treatment.

Goal(s): This study aims to investigate the neurobiological mechanisms of StD by analyzing functional connectivity (FC) and cognitive function in comparison to MDD.

Approach: Whole-brain FC was calculated using seeds from 4 network and cognitive function was assessed of 153 StD individuals, 188 MDD patients and 110 healthy controls (HCs).

Results: StD showed social cognition deficit and dysfunction of the salience network(SN) and affective network(AN). MDD showed multi-domain impairments and dysfunction of the SN and AN and default model network.

Impact: Abnormal SN/AN connectivity may cause depressive symptoms in StD/MDD. Altered DMN FC may trigger disease onset. StD first shows social cognition deficit linked to SN.

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Keywords