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Abstract #2495

Intrinsic connectivity disorganization of anterior cingulate cortex functional subdivisions in major depressive disorder

Zilin Zhou1, Lianqing Zhang1, Xinyue Hu1, Lingxiao Cao1, Weijie Bao1, Yingxue Gao1, Hailong Li1, Huaiqiang Sun1,2, Qiyong Gong1,2,3, and Xiaoqi Huang1,2,3
1Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, 2Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, 3The Xiamen Key Lab of Psychoradiology and Neuromodulation, West China Xiamen Hospital of Sichuan University, Xiamen, China

Synopsis

Keywords: Functional Connectivity, fMRI (resting state), major depresive disorder, connectivity-based parcellation, anterior cingulate cortex

Motivation: The fine-grained boundary and number of anterior cingulate cortex (ACC) functional subdivisions and their anomalous connectivity architectures in major depressive disorder (MDD) remained undetermined.

Goal(s): To obtain optimal ACC functional subdivisions and discern intrinsic connectivity alterations of ACC subregions related to MDD.

Approach: We utilized a data-driven connectivity-based parcellation to define optimal ACC partitions, and identified MDD-related ACC subregional functional connectivity abnormalities and their relationship with clinical manifestations.

Results: A bipartite ventral-dorsal ACC per hemisphere was identified as optimal parcellation. We further discovered ventral ACC-based hypoconnectivity and dorsal ACC-based hyperconnectivity with default mode network in MDD, which held relevance to different clinical symptoms.

Impact: Our discovery of differentiated connectivity architectures of CBP-derived ventral-dorsal ACC functional bipartitions in MDD, with a ventral ACC-based hypoconnectivity related with core depressed symptoms while a dorsal ACC-based hyperconnectivity linked to maladaptive behaviors, could potentially guide more precise targeted interventions.

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