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Abstract #2499

Structure-function coupling changes and associated neurotransmitter systems in high-functioning ASD patients

Baorong Gu1, Huaijin Gao1, Rui Qian1, Xiaoyi Pang1, Dan Wu1,2, and Zhiyong Zhao1,2
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, Autisim disorder spectrum; Neurotransmitter

Motivation: The alterations of structure-function couplings (SFC) in high-function autism spectrum disorder (ASD) and their associations with neurotransmitter systems remain insufficiently elucidated.

Goal(s): We aimed to investigate differences of SFC between ASD and typically developing controls (TDCs) and their relationships with neurotransmitter systems.

Approach: The SFC was derived from T1-weighted images and resting-state fMRI. Two-sample t-tests were used for group comparisons, and Pearson correlations were applied to examine relationship between SFC and neurotransmitter density.

Results: Decreased SFCs in the frontoparietal network were observed in high-function ASD compared to TDCs, correlating with specific neurotransmitter systems.

Impact: Our findings suggested structure-function uncoupling in high-function ASD, which was associated with patients’ communication dysfunction and specific neurotransmitters. This may offer a new perspective on elucidating the underlying neurobiological mechanisms of the dysfunctions in ASD.

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