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Abstract #2505

Clinically feasible resting-state functional MRI as an alternative to preoperative language and motor task-based functional MRI

Isabella Verdon1,2, Jane Ansell1, Ayisha Albusaidi3, Jozef Jarosz3, and Marco Borri1
1Medical Engineering and Physics, King's College Hospital, London, United Kingdom, 2School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 3Neuroradiology, King's College Hospital, London, United Kingdom

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), Preoperative functional mapping

Motivation: Resting-state functional MRI (rs-fMRI) could aid neurosurgical planning for patients unable to perform task-based (tb-)fMRI tasks, however, complex analyses and lack of validated seeds for language mapping hinder clinical adoption.

Goal(s): Develop a clinically feasible, automated rs-fMRI pipeline for language and motor mapping, optimised for comparability to tb-fMRI.

Approach: We developed a pulse sequence, automated preprocessing and analysis pipeline, with standardised seeds. Results from 10 healthy volunteers were compared to atlases and tb-fMRI.

Results: Language and motor resting-state networks (RSNs) showed high sensitivity and high/moderate specificity compared to atlases. Optimal RSN thresholds for comparability to tb-fMRI were identified, producing moderate overlap with tb-fMRI.

Impact: The automated resting-state functional MRI (rs-fMRI) pipeline, using standardised seeds, produces resting-state networks optimised for comparison with task-based (tb)-fMRI and shows promise as an alternative for preoperative language and motor mapping. Future work will explore language lateralisation and rs-fMRI-driven tractography.

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Keywords