Abstract #2507

Test-Retest Validation of Pulsatility Measurement Using Resting-State Functional Magnetic Resonance Imaging

Jinhan Chen¹, Hongwei Li¹, Nathan Cross², Jinglei Lv³, Xiaoping P. Hu⁴, Zhensen Chen^1,5, and He Wang^1,5

¹Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ²School of Psychology, The University of Sydney, Camperdown, Australia, ³School of Biomedical Engineering, The University of Sydney, Camperdown, Australia, ⁴Department of Bioengineering, University of California Riverside, Riverside, CA, United States, ⁵MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China

Synopsis

Keywords: fMRI Analysis, fMRI Analysis

Motivation: Pulsatility measurement using rsfMRI is an emerging technique for assessing brain health. However, its reliability is unclear.

Goal(s): To investigate reliability of pulsatility measurement using nSD method and its consistency between 2D-PC.

Approach: 7 subjects underwent two rsfMRI sessions. Correlation between PI calculated from 2D-PC and nSD pulsatility in the corresponding downstream vascular territories was also assessed.

Results: Test-retest reliability of nSD fMRI pulsatility mapping was moderate and showed a positive correlation with 2D-PC.

Impact: The nSD pulsatility demonstrated moderate reliability, suggesting that further evaluation and optimization of imaging protocol and algorithm are needed before broader application.

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