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Abstract #2509

Mid-term Interval Reliability of Multi-echo based Resting-state Functional Connectivity on a Compact 3T Scanner

Daehun Kang1, Kirk M Welker1, Myung-Ho In1, Dora Hermes2, John Huston III1, Joshua D Trzasko1, and Yunhong Shu1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Physio & Biomed Engineering, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, Multi-echo fMRI, Mid-term interval, Reliability, Intraclass correlation

Motivation: The consistency of cerebral functional connectivity (FC) over mid-term intervals of a few weeks remains unclear given anticipated daily variation in states of emotion or alertness. Multi-echo EPI acquisition (ME) can offer higher signal-to-noise and potentially enhance reliability, compared to single-echo acquisition (SE).

Goal(s): To assess mid-term FC reliability with ME RS-fMRI.

Approach: Test-retest reliability over a 2-to-3-week interval was evaluated using intra-class correlation (ICC) with ROI-based FC matrix and compared with SE.

Results: ME provided higher averaged ICC and detected more connectivity with high ICC than SE. A high- FC matrix thresholded with high ICC was presented.

Impact: A reliability-based thresholding method may offer an alternative approach than traditional FC strength-based methods for assessing mid-term brain connectome changes.

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