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Abstract #2519

Neuroplasticity associates with glymphatic dysfunction during recovery after capsular and pontine stroke

Yueyan Bian1,2, Jiajia Zhang1,2, Yifei Zhang3, Hongxia Zhang4, Xiuqin Jia1,2, and Qi Yang1,2
1Department of Radiology, Beijing Chaoyang Hospital, Beijing, China, 2Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, China, 3Department of Radiology, GE Healthcare MR Research, Beijing, China, 4Department of Radiology, Beijing Bo’ai Hospital, Beijing, China

Synopsis

Keywords: Stroke, Stroke, cerebrovascular reactivity; diffusion tensor image analysis along the perivascular space.

Motivation: Ischemic stroke induces neuroplasticity and glymphatic dysfunction, but their association in stroke patients remains unclear.

Goal(s): To investigate association between neuroplasticity and glymphatic dysfunction during stroke recovery.

Approach: We investigated the association during recovery in patients with capsular stroke (CS) and pontine stroke (PS) by measuring noninvasive MRI-derived cerebrovascular reactivity (CVR) and the diffusion tensor imaging along the perivascular space (DTI-ALPS) index.

Results: We found negative, long-term, bidirectional associations between neuroplasticity and glymphatic dysfunction in CS and PS patients, suggesting a sustained mutual influence between them during stroke recovery.

Impact: Negative, long-term, and bidirectional associations between neuroplasticity and glymphatic dysfunction were observed in stroke patients during recovery. The negative characteristics suggested that neuroplasticity might cause glymphatic dysfunction, and the long-term, bidirectional characteristics suggested a sustained mutual influence during stroke recovery.

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