Keywords: Stroke, Stroke, cerebrovascular reactivity; diffusion tensor image analysis along the perivascular space.
Motivation: Ischemic stroke induces neuroplasticity and glymphatic dysfunction, but their association in stroke patients remains unclear.
Goal(s): To investigate association between neuroplasticity and glymphatic dysfunction during stroke recovery.
Approach: We investigated the association during recovery in patients with capsular stroke (CS) and pontine stroke (PS) by measuring noninvasive MRI-derived cerebrovascular reactivity (CVR) and the diffusion tensor imaging along the perivascular space (DTI-ALPS) index.
Results: We found negative, long-term, bidirectional associations between neuroplasticity and glymphatic dysfunction in CS and PS patients, suggesting a sustained mutual influence between them during stroke recovery.
Impact: Negative, long-term, and bidirectional associations between neuroplasticity and glymphatic dysfunction were observed in stroke patients during recovery. The negative characteristics suggested that neuroplasticity might cause glymphatic dysfunction, and the long-term, bidirectional characteristics suggested a sustained mutual influence during stroke recovery.
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