Abstract #2527

DCE-MRI measures of BBB permeability 6 months after clinical ischaemic stroke

Olivia A Jones^1,2, Zuzanna Biesiada^1,2, Hamied A Haroon^1,2, T J Grundy^1,2,3, Andrew Greenhalgh^1,2, Owen M Thomas^2,4, Ben R Dickie^1,2, Stuart M Allan^1,2, Craig J Smith^1,2,3, Marion S Buckwalter^5,6, and Laura M Parkes^1,2

¹Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, ²Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, United Kingdom, ³Manchester Centre for Clinical Neurosciences, Manchester Academic Health Science Centre, Salford, United Kingdom, ⁴Department of Radiology, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ⁵Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States, ⁶Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Stroke, DSC & DCE Perfusion, Blood-brain barrier, blood vessels, dynamic contrast-enhanced MRI, DCE-MRI

Motivation: Chronic blood-brain barrier (BBB) disruption may play a role in post-stroke cognitive decline, but the relationship has not been characterised in the clinical stroke population.

Goal(s): Describe patterns of BBB permeability 6 to 9 months after clinical ischaemic stroke.

Approach: Patients underwent DCE-MRI to measure BBB permeability (K^trans) and blood plasma volume (v_p) 6-9 months after ischaemic stroke and were compared to vascular risk-matched and healthy controls. Comprehensive cognitive testing is carried out yearly.

Results: Spatial patterns of high K^transand v_pwere variable across the cohort. K^transin previously infarcted and hyperintense FLAIR tissue was significantly greater than in normal-appearing white matter.

Impact: Our characterisation of DCE-MRI measurements of BBB permeability 6 months after clinical ischaemic stroke contributes to the understanding of vascular and immune pathophysiology in the months after stroke and its potential relationship with cognitive decline in the years after stroke.

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