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Abstract #2536

Improved Visibility of Diffuse Gliomas using Multi-delay Pseudo-continuous ASL with a Variable-TR Scheme

Koji Yamashita1, Makoto Obara2, Osamu Togao1, Ryoji Mikayama1, Kazufumi Kikuchi1, Masaoki Kusunoki1, Tatsuhiro Wada1, Chiaki Tokunaga1, Marc Van Cauteren2, and Kousei Ishigami1
1Kyushu University, Fukuoka, Japan, 2Philips Japan, Tokyo, Japan

Synopsis

Keywords: Tumors (Pre-Treatment), Neuro

Motivation: The multi-delay ASL-cerebral blood flow (CBF) offers superior diagnostic performance compared to single-delay ASL-CBF for glioma grading. Furthermore, arterial transit time (ATT) and dynamic signal intensity (SI) changes may also be key factors in differentiating diffuse gliomas.

Goal(s): To determine if time-intensity profiles with multi-delay ASL could distinguish among diffuse gliomas.

Approach: The SI peak time was obtained based on the time-intensity curve. The SI peak time and ATT were compared between diffuse gliomas with IDH-wildtype and IDH-mutant.

Results: IDH-wildtype gliomas showed a shorter SI peak time than with IDH-mutant gliomas. IDH-mutant astrocytomas show longer ATT than IDH-wildtype gliomas.

Impact: The multi-delay PCASL with a variable-TR technique facilitates the identification of increased blood flow regions in diffuse gliomas at the optimal timing. New insights related to dynamic parameters play a vital role in the diagnosis and treating adult-type diffuse gliomas.

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