Meeting Banner
Abstract #2538

Td-dMRI helps predict 1p/19q codeletion status in IDH-mutant gliomas

Xinli Zhang1, Peng Sun2, and Jing Wang1
1Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Department of Clinical & Technical Solutions, Philips Healthcare, Beijing, China

Synopsis

Keywords: Tumors (Pre-Treatment), Tumors, glioma

Motivation: The diagnostic performance of time-dependent diffusion-weighted imaging in predicting the 1p/19q codeletion status in IDH-mutant gliomas remains unclear.

Goal(s): To investigate the clinical value of time-dependent diffusion MRI–based microstructural mapping for noninvasive prediction of 1p/19q codeletion status in IDH-mutant gliomas.

Approach: A prospective collection of patients with IDH-mutant brain gliomas was conducted to evaluate the microstructural differences between the 1p/19q codeleted and non-codeleted groups. The diagnostic performance of each feature was assessed using ROC analysis.

Results: Microstructural parameters, including D, Vin and Cellularity, are efficient in predicting 1p/19q codeletion status in IDH-mutant gliomas.

Impact: Time-dependent diffusion-weighted imaging provides a non-invasive approach to characterize microstructural features, including cell size and density. It shows promise in predicting the 1p/19q codeletion status in IDH-mutant gliomas, potentially aiding clinicians in selecting optimal treatment strategies and conducting prognostic analyses.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords