Abstract #2547

nTMS-Based Tractography Assessment After Brain Tumor Resection: Understanding the Neuroplasticity of the Motor Areas

Hohana Gabriela Konell^1,2, Luan Rafael Aguiar dos Santos^3,4, Allan Dias Polverini⁵, Lizanilda L. G. Albuquerque⁴, Everton Horiquini-Barbosa³, Fernanda Chavaglia³, Daniel Grossi Marconi³, Sapna Kumar⁶, Dylan J. Edwards⁶, Antonio C. dos Santos², and Taiza Edwards^3,7

¹Data Core, Digital Health, Barretos Cancer Hospital, Barretos, Brazil, ²Center for Imaging Sciences and Medical Physics of the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, ³Rehabilitation Center for Barretos Cancer Hospital, Barretos, Brazil, ⁴Department of Neurosciences and Behavioral Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, ⁵Neurosurgical Oncology Division, Barretos Cancer Hospital, Barretos, Brazil, ⁶Moss Rehabilitation Research Institute, Thomas Jefferson University, Philadelphia, PA, United States, ⁷School of Allied Health, The University of Western Australia, Perth, Australia

Synopsis

Keywords: Tumors (Post-Treatment), Brain Connectivity

Motivation: There is limited understanding of neuroplasticity in motor areas after brain tumor resection. The need for better post-surgery assessments of motor function recovery and neuroplastic changes motivated this study.

Goal(s): The study aimed to evaluate neuroplastic changes in motor pathways following brain tumor resection using nTMS-guided tractography, with a focus on structural connectivity.

Approach: nTMS-guided tractography was used to assess changes in the corticospinal tract (CST) and motor lateralization at 1 and 3 months post-surgery.

Results: Significant changes in structural connectivity and motor lateralization were observed in some patients, with increased FA and improved lateralization, suggesting neuroplasticity and motor recovery after tumor resection.

Impact: The results could impact brain tumor surgery and rehabilitation, providing insights into post-surgical recovery of motor function. Future research could explore the mechanisms of neuroplasticity, guiding rehabilitation strategies to optimize functional outcomes in patients.

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