Abstract #2558

Radiomics analysis of non-enhancing lesions after Bevacizumab administration in recurrent glioblastoma

Takahiro Sanada^1,2, Manabu Kinoshita^1,3, Takeshi Shimizu¹, Yoshiko Okita^3,4,5, Hideyuki Arita^3,4, Hirotaka Sato¹, Masato Saito¹, Nobuyuki Mitsui¹, Satoru Hiroshima¹, Mishie Tanino⁶, Yonehiro Kanemura^7,8, and Haruhiko Kishima⁴

¹Neurosurgery, Asahikwa Medical University, Asahikawa, Japan, ²Neurosurgery, Japanese Red Cross Kitami Hospital, Kitami, Japan, ³Neurosurgery, Osaka International Cancer Institute, Osaka, Japan, ⁴Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan, ⁵Neurosurgery, Faculty of Medicine, Miyazaki University, Miyazaki, Japan, ⁶Diagnostic Pathology, Asahikawa Medical University Hospital, Asahikawa, Japan, ⁷Neurosurgery, NHO Osaka National Hospital, Osaka, Japan, ⁸Biomedical Research and Innovation, Institute for Clinical Research, NHO Osaka National Hospital, Osaka, Japan

Synopsis

Keywords: Tumors (Post-Treatment), Radiomics

Motivation: Identifying non-contrast-enhancing tumor (nCET) in glioblastoma (GBM) is crucial for surgical treatment. However, T2/FLAIR images are unable to reliably distinguish nCET from vasogenic edema (VE).

Goal(s): To develop an MRI-based method to identify nCET via radiomic features on areas where CET transformed to nCET after BEV administration.

Approach: Radiomic features were analyzed in an exploratory cohort under BEV treatment (n=24) and a validation cohort who underwent 11C-methionine positron emission tomography (n=23).

Results: A combination of three imaging features distinguished nCET from VE (AUC=0.91) with high positive predictive accuracy. Reconstructed MRI images also provided reasonable nCET visualization in newly diagnosed GBMs.

Impact: Radiomic features of lesion where CET transformed into nCET after BEV administration may provide valuable information in predicting nCET in GBM.

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