Abstract #2562

Comparison of long-label single-delay ASL and multi-delay ASL in healthy aging

Banafsheh Shakibajahromi¹, Jiekai Zhu², Sipei Li², Manuel Taso³, John A Detre⁴, and Sudipto Dolui⁵

¹Neurology, University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Siemens Medical Solutions USA, Malvern, PA, United States, ⁴Neurology and Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁵Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Aging, Aging, Brain,Perfusion, ASL

Motivation: Identify the most sensitive arterial spin labeling (ASL) methods for brain aging

Goal(s): Compare single- and multiple-post labeling delay (PLD) ASL protocols in healthy aging

Approach: Absolute cerebral blood flow (CBF), relative CBF, and arterial transit time (ATT) from long-label (LL) single-PLD and multi-PLD sequences were correlated with age and other variables in an adult lifespan cohort.

Results: Age effects were more significant in ATT and ATT-corrected CBF values than in LL single-PLD CBF, though the use of putamen-normalized relative single-PLD CBF enhanced sensitivity to age and other biological parameters.

Impact: Multi-PLD ASL enhances the assessment of age effects on brain perfusion.

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