Abstract #2566

Cerebrovascular Reactivity Development in Infants during the First Two Years of Life Using Resting-State BOLD Functional MRI

Baorong Gu¹, Rui Qian¹, Zilong Ye¹, Bowen Qiu¹, Zichao Li¹, Mingyang Li¹, Ruoke Zhao¹, Yuqi Zhang¹, Yutian Wang¹, Peiying Liu², Hanzhang Lu³, Dan Wu¹, and Zixuan Lin¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ³Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Normal Development, Vascular, resting-state fMRI, BOLD, cerebrovacular reactivity, neurotransmitter, developmental trajecotry

Motivation: There is no systematic research focused on the development of cerebrovascular reactivity (CVR) in infants.

Goal(s): This study aims to investigate the early development of CVR with resting-state BOLD analysis.

Approach: We mapped CVR from BCP dataset and fitted developmental trajectory from 1 to 24months. The relationship between CVR and cognitive abilities as well as its association with neurotransmitter receptors/transporters was also investigated.

Results: Multiple brain regions showed significant age effect of CVR. CVR at the left superior frontal gyrus was associated with expressive language. GABAaR, mGluR5 and VAChT were found to be related to CVR development as well.

Impact: We demonstrated the feasibility of utilizing resting-state BOLD to evaluate the development of CVR in infants, revealing the potential neurotransmitter receptors/transporters system involved. This approach offers a novel perspective on assessing cerebrovascular health in infants.

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