Abstract #2570

Morphological and Functional Development of Glymphatic System in 0-8 Year Old Children : Age-Dependences and Correlation

Chunxu Da^1,2,3,4, Congcong Liu¹, Chenyue Liu¹, Miaomiao Wang¹, Xinyi Huang¹, Xianjun Li¹, Feng Shi⁵, and Jian Yang^1,2,3,4

¹The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China, ²Xi’an Jiaotong University Health Science Center, Xi'an, China, ³Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence,, Xi'an, China, ⁴Xi’an Key Laboratory of Medical Computational Imaging, Xi’an, China, Xi'an, China, ⁵Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai, China

Synopsis

Keywords: Normal Development, Normal development

Motivation: Glymphatic system abnormalities mediate multisystem pediatric diseases. To further clarify the alterations of glymphatic system in pathological conditions, reliable researches on normal development of glymphatic system in early lifetime are required.

Goal(s): Quantitatively evaluate the structure and function of PVS in children aged 0–8, and clarify a developmental pattern of glymphatic system.

Approach: PVS in certain plane was identified and measured with an automated segmentation method, the DTI-ALPS method was applied to assess glymphatic system function, and statistical correlation between was required.

Results: Developmental patterns of PVS morphological characteristics and glymphatic system function in 0–8 years were clarified, revealing a significant correlation between.

Impact: Between age and both PVS morphological metrics and glymphatic system function, a positive correlation has been established across the 0–8 year age range for the first time. Furthermore, correlation between glymphatic system structure and function was quantitatively confirmed.

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