Keywords: Pulse Sequence Design, Acquisition Methods
Motivation: Conventional T1 structural MRI provides excellent overall brain morphology; however, limited in midbrain subnucleus imaging. Enhanced MR of the midbrain substructures such as substantia nigra is crucial in accurately targeting a specific subnuclei for deep-brain-stimulation or in neuro-melanin (NM) measurement for Parkinson’s and bipolar disease.
Goal(s): To develop simultaneous T1MPRAGE, FGATIR and NM acquisition in clinical acceptable time, ~10min
Approach: Three imaging blocks of T1MPRAGE, FGAITR, and NM acquisition are concatenated after adiabatic inversion RF in single TR.
Results: New sequence for simultaneous T1MPRAGE, FGATIR and NM acquisition was successfully developed and the feasibility of each unique contrast imaging was demonstrated.
Impact: The advantages of new sequence could be beneficial for pre-surgical planning for accurate targeting a subnuclei, and NM measurement in Parkinson's or bipolar disease study, by providing whole brain anatomy, midbrain subnuclei and SN internal differentiation.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords