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Abstract #2589

Rapid Dual-component UTE (RaD-UTE) imaging of bound and pore water in cortical bone

Jiyo S Athertya1, Arya Suprana1,2, Michael Carl3, Shengwen Xie1, James Lo1,2, Soo Hyun Shin1, Saeed Jerban1, Eric Y Chang1,4, Yajun Ma1, Christine B Chung1,4, and Jiang Du1,2,4
1Department of Radiology, UCSD, San Diego, CA, United States, 2Department of Bioengineering, UCSD, San Diego, CA, United States, 3GE Healthcare, San Diego, CA, United States, 4Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: Signal Modeling, MSK, UTE imaging, bone imaging

Motivation: Cortical bone has two distinct water components: pore water and bound water. Pore water reflects cortical porosity, while bound water is related to organic matrix density.

Goal(s): To develop fast MRI technique to map bound and pore water in cortical bone.

Approach: The rapid dual-component ultrashort echo time (RaD-UTE) technique employs 3D UTE multi-echo acquisitions for fast volumetric mapping of bound and pore water, including their T1 and T2*s relaxation times as well as T1-corrected bound and pore water fractions.

Results: RaD-UTE allows fast volumetric mapping of bound and pore water T2*, T1, and T1-compensated fractions.

Impact: The RaD-UTE technique allows fast volumetric mapping of bound and pore water T1, T2*s, and fractions, and has great potential for accurate mapping of cortical porosity and organic matrix density under clinical acceptable scan time.

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